Swansea City striker missed Monday’s workout at the Accra Sports Stadium and will not travel with the team, citing a stomach upset while Afful has opted out because of foot injury.
The setback denied him a starting role in last Friday's 1-1 draw with the Red Devils at the Baba Yara Stadium in Kumasi.
He came on as a second half substitute and seems to have aggravated the injury.
Already, captain, Asamoah Gyan and his deputy, Andre Ayew have omitted themselves due to injuries.
The Black Stars need victory in Congo to have a mathematical chance of bouncing back in the World Cup qualification, especially should Uganda hold Egypt in Alexandria in the other Group E match.
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