Nicknamed the Black Stars, the team last Thursday drew 1-1 against the Bafana Bafana of South Africa to boon a ticket to the tournament scheduled to be staged in Cameroon next January.
Ahead of kick-off at 16:00GMT, Ghana coach CK Akonnor has named a strong first eleven to do battle for his side.
Jordan Ayew and Andre Ayew return to the starting lineup alongside Thomas Partey.
The trio missed the last match in South Africa but have been handed roles to help the team look for a win.
Below is the Black Stars first eleven for the São Tomé and Principe match:
Ghana ???????? XI vs Sao Tome and Principe
16.Razak Abalora 2.Benson Anang 17.Baba Abdul Rahaman 4.Nicholas Opoku 27.Ganiyu Ismail 11.Mubarak Wakaso 5.Thomas Partey 7.Osman Bukari 9.Jordan Ayew 10.Dede Ayew 20.Mohammed Kudus Read Full Story
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