The West African giants left Dubai at exactly 10:00am (6:00amGMT) on Friday and are expected to arrive in Cairo by 9:00GMT.
The Ghanaians wrapped up their camping with a friendly match against the Bafana Bafana of South Africa which ended in a goalless draw.
They are expected to stage a stupendous outing at the tournament as they seek to lift the trophy this year after 37-years of trying without success.
The four-time African champions will open their Group F fixture against Benin on June 25, play title holders Cameroun on June 29 and wrap it up with a game against Guinea-Bissau on July 2.
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