Known by his moniker 'General Mosquito', Mr Asiedu Nketia routed his Deputy and only contender in the two-man race, Mr Koku Anyidoho.
According to provisional results, Mr Nketia, a three-time former MP for Wenchi West Constituency in the Brong Ahafo Region, from 1993 to 2000, who was first elected as General Secretary in 2008, polled 6,644 while Mr Anyidoho could only manage 1,655 votes.
Seven of the ballots were rejected.
Ahead of the polls, the party's former Central Regional Chairman, Mr Bernard Allotey Jacobs, unfurled a barrage of accusations and allegations against the 62-year-old incumbent General Secretary and described him as a dictator within the party.
Mr Jacobs also expressed confidence of victory for Mr Anyidoho, known by his moniker 'The Bull'.
It is not clear what becomes of Mr Anyidoho's political career after failing to unseat his boss.
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