The Black Stars midfielder returns to the team after he was rested over the weekend in the Nerazzuri's 2-0 win over Cagliari in the Serie A on Saturday.
Asamoah who joined the Milan club in the summer has been one of the key players at the club this season helping the club to a good start in the Champions League.
The 29 year old provided a sweet assist in the first game against Tottenham Hotspurs as they came back from a goal down to record a 2-1 win over the English Club.
Inter Milan returned to the Champions League after a six year absence.
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