Mrs. Trump will be welcomed into the country by Ghana's First Lady, Rebbeca Akufo-Addo and others at the Kotoka International Airport in Accra.
The US First Lady's nearly week-long trip will take her around four countries on the African continent; Ghana, Malawi, Kenya and Egypt.
She is expected to donate some items to the Accra Regional Hospital as she focuses on issues affecting children.
The First Lady who seems excited about her tour, has earlier described her host nations as “four beautiful and very different countries”.
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