The guitarist, producer and vocalist rose to fame when he featured on Paul Simon's Graceland album in 1986.
He was admitted to hospital a few days ago, while a public appeal was launched to help pay for his medical bills.
In an interview with The Sowetan newspaper earlier this month, Phiri said:
"Let me suffer [in peace with my] pain, on my own with my dignity." Tributes have been pouring in for Phiri on Twitter, with people using the hashtag #RIPRayPhiri: Read Full Story

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