However, Lokomotiv head into the fixture at Wanda Metropolitano aware that recording maximum points against the La Liga giants would move them into second place in Group A.
After the 4-0 defeat to Bayern Munich on matchday one, Diego Simeone would have recognised that Atletico were already playing for second place behind the 2020 champions.
That increased the pressure ahead of a home fixture with highly-rated Red Bull Salzburg, who led 2-1 at Wanda Metropolitano before succumbing to a 3-2 defeat.
While that put Atletico in a situation where they could have put breathing space between themselves and the chasing pack, Simeone witnessed his Los Rojiblancos side only claim a draw at Lokomotiv Moscow.
Although Simeone and his players will be content with a two-point advantage over Lokomotiv at this stage of the group, there is now little margin for error with Bayern and a trip to Salzburg still to come.
Atletico will take confidence from their 1-0 triumph over Barcelona at the weekend. Having been provided with an exceptionally tough group, Lokomotiv will be delighted to still be in contention for a last-16 spot at the midway point.
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