Antwi-Adjei crowned a magnificent performance with his side's third as they defeated Raman Chibsah's Bochum 3-0.
The 27-year-old has been in top form for the Blue and Blacks and was on target when they lost to Nuremberg last week.
Julian Justvan and Sven Michel scored to quick fire goals to hand Paderborn a first half lead before Antwi-Adjei added a third with 17 minutes left.
The goal was the Ghana international's third of the season after 25 matches.
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