The Ghana international smashed one past goalkeeper Ramsdale on four minutes after Wilfred Zaha broke down the left, cut back to Christian Benteke who fed Schlupp.
It was the club's fastest English Premier League goal since 2017.
But Schlupp had to replaced after 39 minutes by Nigerian Eberechi Eze who scored the second goal.
The 28-year-old has scored two goals this term in 15 league appearances.
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