The 26-year-old lasted the entire duration as the home side secured a vital point at Benteler Arena.
Danish international Skov netted for Hoffenheim after just four minutes.
But a dreadful blunder by Hoffenheim defender Ermine Bicakcic five minutes later gifted the ball to Paderborn's Srbeny, and the striker curled home for the equaliser.
Despite plenty of chances in an open, free-flowing game, neither side could manage another goal.
The draw leaves Paderborn bottom of the table on 18 points, while Hoffenheim are ninth on 36.
Christopher Antwi-Adjei has been one of the consistent players for Paderborn this term, making 27 appearances in the Bundesliga. Read Full Story
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